Journal article
Disease specific determinants of cardiopulmonary fitness in systemic sclerosis
L Ross, B Costello, A Lindqvist, D Hansen, Z Brown, W Stevens, A Burns, D Prior, M Pianta, W Perera, A La Gerche, M Nikpour
Seminars in Arthritis and Rheumatism | Published : 2023
Abstract
Objectives: We aimed to quantify the burden of exercise intolerance in systemic sclerosis (SSc) and explore the disease features that contribute to impaired exercise capacity (measured as peak oxygen uptake, peak VO2) to provide novel mechanistic insights into the causes of physical disability in SSc. Methods: Thirty-three SSc patients with no history of cardiac disease and no active myositis underwent cardiac and skeletal muscle MRI, transthoracic echocardiography, pulmonary function tests and cardiopulmonary exercise testing (CPET). CPET results were compared to an age-, sex-, and weight-matched controls with no overt cardiopulmonary disease. Native T1 and T2-mapping sequences were used to..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by a National Heart Foundation of Australia Vanguard Grant (102206] , Arthritis Australia - Australian Rheuma-tology Association Project Grant, Scleroderma Victoria Project Grant, St Vincent's Hospital Research Endowment Fund Project Grant (88371) and The University of Melbourne Research Establishment Grant. LR is supported by a MSK Australia PhD Scholarship and an Australian Government Research Training Program Scholarship. ZB is supported by a University of Melbourne Research Training Scholarship. ALG holds an Australian National Heart Foundation Future Leader Fellowship (1020210) . MN holds a National Health and Medical Research Council of Australia Investigator Grant (GNT 1176538) .